Nitrazepam: hypnotic drug

Nitrazepam 10mg Schedule IV, a hypnotic drug used for temporary relief from severe anxiety,insomnia, difficulty in falling asleep, early or frequent awakening during sleep, to treat a certain form of seizures like myoclonic seizures and treatment of the west syndrome. It has sedative properties, including anticonvulsants, amnesia, and muscle relaxant effects. It helps reduce the abnormal activity of the nerve cells and calms the brain, thereby shortening the time required to sleep and lengthens the duration of sleep.  NITRAZEPAM sleeping tablets are available under different brand names.

Nitrazepam: Constituents

Each NITRAZEPAM 5mg or 10mg tablet contains Nitrazepam, microcrystalline cellulose, magnesium stearate, and sodium croscarmellose.


NITRAZEPAM dosage is to be taken as prescribed by the doctor, only before bedtime, depending upon personal needs, other medications, and medical conditions. Dosage cannot be increased or reduced.

It has to be carefully administered by the doctor since it is a habit-forming drug. In case of missed dose patient should not take two doses together; only dose due is to be taken. The drug may stop showing its effects if it is used for a prolonged period; it is only recommended to be prescribed for a short time period, usually not more than 7-10 days consecutively.

The doctor or poison control center should be immediately consulted in case of overdose. Dosage should not be stopped suddenly, since it may cause serious withdrawal symptoms; rather, it should be reduced gradually as recommended by the doctor.

If NITRAZEPAM is being taken for myoclonic seizures, the dose depends on body weight, child dose (up to 30kg bodyweight) may range from 0.3 per kg to 1mg per kg 3 times in a day.


There are certain type of precautions that must be followed before starting NITRAZEPAM medication, this includes proper insight into the cause of insomnia, informing your doctor about in case you are allergic to any type of medication specially Nitrazepam or benzodiazepines or those who have history of myasthenia gravis or if there is family history of allergy of any type. Patients with a history of galactose intolerance, glucose-galactose malabsorption, or lactase deficiency should not be prescribed with NITRAZEPAM.

IN any problem of kidney or liver impairment or any type of chemical dependency, any signs of depression, or muscle problems or patients suffering from sleep apnea doctor should be consulted.

While taking Nitrazepam, patients must reduce the use of alcohol. Also, its use should be discontinued in case the patient is unable to get a full night’s sleep.

Any type of work that involves attentiveness or motor skills like driving or operating any machinery should be avoided since it may cause motor impairment leading to serious accidents.

NITRAZEPAM 10mg is to be given in mild doses (2.5mg) for elderly patients to be taken at bedtime; it is not recommended to prescribe NITRAZEPAM is avoided to pregnant or lactating mothers (it passes in breast milk) since it may cause serious side effects to the fetus. Patients with a feeling of depression or suicidal thoughts should refrain from taking benzodiazepines. NITRAZEPAM interacts with alcohol, iron supplements, allergy supplements, narcotic containing medicines, calcium channel blockers, tricyclic antidepressants, birth control pills, benzodiazepines, serotonin reuptake inhibitors, barbiturates, azole antifungal medications, Opioids, Primaquine, and Antihypertensives.

Drug Interaction

Foods such as grapefruit, dark chocolates, coffee should also be consumed after consultation.


NITRAZEPAM 10mg should be stored at room temperature away from moisture, direct heat, or light, at a temperature of 15-30 degrees Celsius, strictly to be kept out of reach of children. Once dependence on NITRAZEPAM has developed, its sudden termination may lead to serious withdrawal symptoms. This may include depression, rebound insomnia, nervousness, diarrhea, or sweating. In rare cases, it may lead to confusional states, psychotic manifestations, and convulsions. It may also lead to anterograde amnesia combined with behavioral problems. It may also cause reactions like aggressiveness, delusions, hallucinations, rage, nightmares, inappropriate behavior, etc.

Overdose may also lead to depression of the nervous system varying from lethargy to coma or death in rare cases.

Other serious side-effects may include dizziness, fatigue, mental confusion, or loss of coordination.

The doctor should be immediately consulted also in case of any symptom of irregular heartbeat, any change in vision, or speech, depression, confusion, irritability or behavioral change, any type of allergic reaction, trouble in breathing, rash, itching or swelling.

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