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What is clonazepam?
The active substance clonazepam, also marketed under the brand name Rivotril, is a benzodiazepine. It is used mainly as an antiepileptic for children, adolescents and adults. One can buy clonazepam online.
We can find several pharmacological presentations of this medicine. It is marketed in tablets and oral drops, and also as an injectable preparation for intravenous or intramuscular administration.
Clonazepam for Sale asthe intravenous route is generally used for the treatment of ‘status epilepticus’. The intramuscular way, however, must be reserved for exceptional situations.
What is it used for?
Clonazepam is a benzodiazepine and, as such, has an anti-epileptic, sedative, muscle relaxant and anxiolytic effect. However, it is usually used mainly in the treatment of epilepsy.
The therapeutic indications of clonazepam, according to their technical specifications are:
Baby and child epilepsy, especially:
Typical or atypical small illness (absence crises).
Generalized tonic-clonic crisis.
Epilepsy in adults, especially:
Seizures of focal epilepsy.
State of epileptic illness.
It is especially useful in the treatment of absence attacks and atypical absences, although it is also used effectively in panic attacks. Also, it has a high mood-stabilizing ability.
Mechanism of action
Like the rest of benzodiazepines, clonazepam works by increasing neurotransmission mediated by the neurotransmitter GABA, an inhibitor of gamma-aminobutyric acid.
Therefore, this medication increases the affinity of the GABA receptor and enhances its effects when its release is increased.
As we said, GABA is an inhibitory neurotransmitter that relaxes brain excitement and reduces neuron activity. It is related to many disorders, such as depression, schizophrenia, epilepsy, bipolar disorder, etc.
In this sense, clonazepam, by increasing the inhibitory effect of GABA, decreases the activity of the central nervous system, suppressing seizures, for example.
Side effects of clonazepam
The most common adverse reactions in treatment with clonazepam are:
Emotional and mood changes.
Confusion and disorientation.
Paradoxical reactions, such as:
Restlessness and irritability.
Agitation and nervousness.
Delusions and hallucinations.
Eye disorders, such as nystagmus.
In case of detecting undesirable effects derived from the administration of the medication, the specialist should be consulted. He will consider whether a change in treatment is necessary or whether the dose should be adjusted.
It must be individualized for each patient, according to their characteristics and their response to the medication.
Treatment should not be interrupted without medical advice, as it is a drug that can cause addiction and generate an abstinence syndrome. This is especially true with long, high-dose treatments, but also when there are sudden changes in the dose.
The symptoms of withdrawal syndrome are, among others:
Tremors and cramps.
To avoid this, if you need to stop treatment, the specialist will provide guidelines for progressively reducing the dose.
In case of overdose, it is common to observe symptoms such as drowsiness, nystagmus, decreased coordination of movements or difficulty in speech. Sometimes, it is necessary to apply a treatment to combat the symptoms. It may be essential to administer flumazenil, a benzodiazepine antagonist.
It should also be borne in mind that clonazepam is a central nervous system depressant and can enhance the effects of substances such as alcohol. It should also not be combined with drinks with high caffeine content.